OriGen 营业时间

周一至周五：上午 8:00 至下午 4:30 CSTE 邮箱：通用邮箱电话：+1.512.474.7278 免费电话：+1-800-233-9014

技术支持细胞生物学和冷冻保存产品

电子邮件：冷冻保存技术支持电话：+1.512.474.7278

呼吸产品

电子邮件：Liquivent® 技术支持电话：+1.512.474.7278

2020 年脐带血连接虚拟大会 2020 年 8 月 31 日新闻与洞察

2020 年脐带血连接虚拟国际大会是第三届脐带血和围产期组织研究国际会议。

地点：虚拟

日期：2020 年 9 月 10 日和 9 月 17 日

链接：2020 年脐带血连接虚拟最新更新 2023 年 4 月 19 日冷冻保存在再生医学中的重要性 2023 年 4 月 3 日Lab Week 2023 – 虚拟会议门票赠品2023 年 3 月 29 日OriGen 总裁兼首席执行官 Beth San Segundo 在 MFG 奥斯汀播客

关于

监管

会议与活动管理

职业OriGen 营业时间

周一至周五：上午 8:00 至下午 4:30 CSTE 邮箱：通用邮箱电话：+1.512.474.7278 免费电话：+1-800-233-9014

技术支持细胞生物学和冷冻保存产品

电子邮件：冷冻保存技术支持电话：+1.512.474.7278

呼吸产品

电子邮件：Liquivent® 技术支持电话：+1.512.474.7278

OriGen 营业时间

周一至周五：上午 8:00 至下午 4:30 CSTE 邮箱：通用邮箱电话：+1.512.474.7278 免费电话：+1-800-233-9014

技术支持细胞生物学和冷冻保存产品

电子邮件：冷冻保存技术支持电话：+1.512.474.7278

呼吸产品

电子邮件：Liquivent® 技术支持电话：+1.512.474.7278

OriGen 营业时间

周一至周五：上午 8:00 至下午 4:30 CSTE 邮箱：通用邮箱电话：+1.512.474.7278 免费电话：+1-800-233-9014

技术支持细胞生物学和冷冻保存产品

电子邮件：冷冻保存技术支持电话：+1.512.474.7278

呼吸产品

电子邮件：Liquivent® 技术支持电话：+1.512.474.7278

OriGen 客户安全区产品手册分析证书使用说明监管安全数据表技术公告白皮书和使用建议我的帐户使用说明العربية – ar – Aribicбългарски език – bg – Bulgariančeština, český jazyk – cs – Czechdansk – da – DanishDeutsch – de – Germanελληνικì – el – 希腊英语 – en – EnglishEspañol – es – Spanishsuomi, suomen kieli – fi – Finnishfrançais – fr – Frenchmagyar – hu – HungarianItaliano – it – 意大利语日本语 (ニほんご) – ja – 日语한국어 – ko – Koreanlietuvių kalba – lt – 立陶宛语荷兰语, Vlaams – nl – 荷兰语挪威语– 否 – Norwegianjęzyk polski, polszczyzna – pl – PolishPortuguês do Brasil – pt-br – Portuguese (Brazil)Português – pt-pt – Portuguese (Portugal)Română, Moldovenească – ro – 罗马尼亚语；摩尔多瓦语； Moldovanрусский – ru – Russianсрпски језик – sr – SerbianSvenska – sv – SwedishTürkçe – tr – TurkishУкраїнська – uk – 乌克兰中文 (Zhōngwén), 汉语, 汉语 简体字 – zh-cn – 简体中文 ( PRC)中文 (Zhōngwén), 汉语, 汉语 香港– zh-hk – 中文（繁体，香港特别行政区）

注册 OriGen Biomedical 的季度时事通讯，以在您的收件箱中直接接收最新消息、产品发布、教育内容等。

感谢您使用 OriGen 产品！

请完整填写下面的客户产品调查表。

为了表达我们对您花时间完成此调查的感谢，我们将在每个季度选择4 名获奖者可获得价值 10 美元的礼品卡。只需在调查的最底部表明您希望参与并提供必要的联系信息即可。

* = 必填字段。 N/A 不是任何领域可接受的答案。

More Information Product Details Synonyms Product Type Properties Clone Isotype Immunogen/Antigen Application Crossreactivity Purity Detail Formulation Other Product Data Declaration Shipping and Handling Shipping Short Term Storage Long Term Storage Use/Stability Documents MSDS Product Specification Sheet Datasheet

NFKB2; LYT10

Monoclonal Antibody

9D2

Mouse IgG2b κ

Recombinant human His-NFκB (aa 1-454) protein purified from E. coli.

ELISAWestern Blot (1:2,000)

HumanMouseRat

Ammonium sulfate precipitation.

Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.

Click here for Original Manufacturer Product DatasheetOur product description may differ slightly from the original manufacturers product datasheet.

Manufactured by AbFrontier

BLUE ICE

+4°C

-20°C

Stable for at least 1 year after receipt when stored at -20°C.

No

Download PDF

NF-κB (Nuclear Factor κ B) is a nuclear transcription factor found in all cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, ultraviolet irradiation, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection. Consistent with this role, incorrect regulation of NF-κB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection and improper immune development. There are five members in the NF-κB family: NF-κB1, NF-κB2, RelA (also named p65), RelB, and c-Rel.The most common form of NF-κB is the p50/RelA heterodimer, although other forms of NF-κB dimers, such as p50/p50, p52/p52, p52/RelA, p50/c-Rel, c-Rel/c-Rel, p52/RelB, and p50/RelB, have also been identified in some types of cells. The primary role of NF-κB is to maintain normal cellular functions that range from cell-to-cell communication to cell motility, cell cycle progression, and cell lineage development. The activity of NF-κB is tightly regulated by interaction with inhibitory IκB proteins. NF-κ-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-κ-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at κ-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different κ-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-κ-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-κ-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-κ-B inhibitor (I-κ-B) family. In a conventional activation pathway, I-κ-B is phosphorylated by I-κ-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-κ-B complex which translocates to the nucleus. In a non-canonical activation pathway, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-κ-B RelB-p52 complexes. The NF-κ-B heterodimeric RelB-p52 complex is a transcriptional activator. The NF-κ-B p52-p52 homodimer is a transcriptional repressor. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-κ-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. p52 binds to the κ-B consensus sequence 5-GGRNNYYCC-3, located in the enhancer region of genes involved in immune response and acute phase reactions. p52 and p100 are respectively the minor and major form; the processing of p100 being relatively poor. Isoform p49 is a subunit of the NF-κ-B protein complex, which stimulates the HIV enhancer in synergy with p65.Product References1) Campbell KJ, Perkins ND. Cell Cycle. (2004) vol.3(7): p.869-72. (General)2) Perkins ND. Trends Cell Biol. (2004) vol.14(2): p.64-9. (General)3) Zanetti M, et al, Ann N Y Acad Sci. (2003) vol.987: p.249-57. (General)